Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions contain:

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Within the very same time, the group of Paul McEuen, who was then centered with the University of California, Berkeley, confirmed equivalent results on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

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From the yrs pursuing these discoveries, my investigation passions shifted to biophysics and nanobiology, and I turned a lot less involved with the development of nanotube electronics. The focus of numerous researchers in the field also shifted to graphene (where by, funnily plenty of, the primary graphene ribbons had been described as ‘nanotubes which have been Slash open along their duration’) soon after the discovery of The 2-dimensional content in 2004.

Size control of person carbon nanotubes by nanostructuring Using the scanning tunneling microscope

2011, first in vitro measurements of transportation throughout one biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination

2003, demonstrated the initial biosensors produced out of a carbon nanotube; fixed the framework and mechanism of DNA fix proteins; and discovery of a brand new technique for fabricating good-condition nanopores for DNA translocation

‘The fantastically refined way through which factors in nature perform never ceases to amaze me. If we address the puzzle of how lifetime came into becoming, I expect that my amazement within the complexity of development can have increased and with it my awe with the greatness on the Creator.’

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2001, discovery of solitary-electron transistors at room temperature dependant on nanotubes; realization of 1st logic circuits with carbon nanotube gadgets; and discovery of the molecular framework of DNA restore enzymes with AFM

Visualization of unstained DNA nanostructures with Sophisticated in-target transmission electron microscopy tactics

Solid-point out nanopores have demonstrated being a incredibly adaptable probe for solitary-molecule Investigation of DNA. I will describe many of our new results – especially DNA knots – in addition to our efforts to develop the capabilities of strong-point out nanopores cees dekker even even further, while in the path of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.